Vasculitis & polymyalgia rheumatica
Extracellular vesicles exposing complement split products are associated with kidney involvement in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (antibody-associated vasculitis (AAV))
Authors' conclusion
Elevated levels of MPO+EVs exposing complement components in patients with kidney involvement indicate activation of the classical or lectin and common complement pathways in renal AAV.
Study context
- Population
- Patients with AAV: GPA or MPA73 (90.1%) active disease · GPA 59 · or MPA 22
- Participants
- 81 patients
- Exposure
- AAV with kidney involvement vs without kidney involvement
- Kidney involvementn = 50
- Outcome
- Plasma MPO+EVs exposing complement components (C3a, C4d, TCC, complement factor B (CFB)) in relation to disease activity (BVAS) and kidney involvement
Methodological detailsflow cytometry, binary multivariable logistic regression
- Flow cytometry
- Binary multivariable logistic regression
Main finding
As reported in the abstract
MPO+EV concentrations by kidney involvement
- Concentrations correlated positively with Birmingham Vasculitis Activity Score (BVAS)
- p<0.05
Observational data: associations, not effects.
Original publication
Extracellular vesicles exposing complement split products are associated with kidney involvement in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). RMD Open. Published 3 July 2026. doi:10.
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