Vasculitis & polymyalgia rheumatica
Defining cause of death in a contemporary cohort with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV): A comparison of electronic health record and death certificate data
Authors' conclusion
In a contemporary cohort of patients with AAV, infection was the most common cause of death, while death due to AAV itself was rare. We found a high degree of discordance between causes of death determined by manual review and death certificate diagnosis codes.
Study context
- Population
- Patients with AAV in the Mass General Brigham AAV Cohort who died between 2002 and 201972 with electronic health record (EHR) and death certificate data
- Participants
- 184 patients
- Exposure
- Cause of death by EHR review vs death certificate diagnosis codes
- EHR reviewn = 92reference
- Outcome
- Sensitivity of death certificate diagnosis codes for AAV
Methodological detailscomparison of EHR review (reference gold standard) vs death certificate diagnosis codes
- Comparison of EHR review (reference gold standard) vs death certificate diagnosis codes
Main finding
As reported in the abstract
Sensitivity of AAV diagnosis codes for AAV
| Group | Sensitivity |
|---|---|
| Death certificates | 16.6 % (95 % CI: 10.5, 22.6) |
Death certificates
Sensitivity16.6 % (95 % CI: 10.5, 22.6)
Observational data: associations, not effects.
Further findings
Cause of death: AAV, infection, CVD, cancer EHR review 8 %, 29 %, 5 %, 18 % · Death certificates 0 %, 11 %, 25 %, 21 %
AAV
Infection
CVD
Cancer
Original publication
Defining cause of death in a contemporary cohort with ANCA-associated vasculitis (AAV): A comparison of electronic health record and death certificate data. Semin Arthritis Rheum. Published 19 December 2024. doi:10.
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