Vasculitis & polymyalgia rheumatica
Poor prognostic factors for relapse of interstitial lung disease in microscopic polyangiitis: the Japanese multicentre REVEAL cohort study
Authors' conclusion
The initial serum high KL-6 and SP-D levels and the prevalence of the UIP pattern were associated with ILD relapse in patients with MPA-ILD.
Study context
- Population
- Patients with microscopic polyangiitis (MPA) complicated by interstitial lung disease (ILD) treated with immunosuppressive therapy, REVEAL cohort, multiple institutions in Japan, 2001 to 2023of 243 patients with MPA
- Participants
- 134 patients
- Exposure
- Relapsed vs non-relapsed MPA-ILD
- Relapsedn = 28
- Outcome
- Risk factors for ILD relapse after remission induction therapy
Methodological detailsmulticentre, multivariate Cox regression
- Multicentre
- Multivariate Cox regression
Main finding
As reported in the abstract
Risk factors for ILD relapse
Best cut-off of KL-6 for predicting ILD relapse
430 U/mL
Best cut-off of surfactant protein-D (SP-D) for predicting ILD relapse
89.5 ng/mL
Observational data: associations, not effects.
Further findings
- ILD relapse · mean follow-up of 4.2 years — Relapsed
- 20.9%
10-year relapse rate by number of KSU model risk factors
- Significantly different among patients stratified by number of KSU risk factors
All-cause mortality
- Higher relapse rate associated with higher all-cause mortality
Original publication
Poor prognostic factors for relapse of interstitial lung disease in microscopic polyangiitis: the Japanese multicentre REVEAL cohort study. Arthritis Res Ther. Published 19 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →