Vasculitis & polymyalgia rheumatica
Risk prediction model for mortality in microscopic polyangiitis: multicentre REVEAL cohort study
Authors' conclusion
The developed RPM is promising to predict mortality in patients with MPA and provides clinicians with a valuable tool for risk assessment and informed clinical decision-making.
Study context
- Population
- Patients with newly diagnosed microscopic polyangiitis (MPA), multicentre Japanese registry of patients with vasculitis (REVEAL cohort)
- Participants
- 194 patients
- Comparison
- Deceased vs surviving patients with newly diagnosed MPA
- Deathn = 60
- Outcome
- Mortality (risk factors predictive of mortality)
Methodological detailsmulticentre, registry-based (REVEAL cohort), univariate and multivariate analyses
- Multicentre
- Registry-based (REVEAL cohort)
- Univariate and multivariate analyses
Performance
As reported in the abstract
Mortality · median follow-up 202.5 (84-352) weeks
Deaths
60
30.9%
Further findings
| Outcome | Death | Survivors | P value |
|---|---|---|---|
| Age | median 76.2 years | 72.3 years | P < 0.0001 |
| Observation period | median 128.5 (IQR 35.3–248) weeks | 229 (IQR 112–392) weeks |
Causes of death
- MPA-related vasculitis
- 18.3%
- Infection
- 50.0%
- Others
- 31.7%
Baseline characteristics, death vs survivors
- Death group had higher smoking index, lower serum albumin, higher CRP, higher Birmingham Vasculitis Activity Score (BVAS), higher Five-Factor Score and more severe EUVAS categorization
Original publication
Risk prediction model for mortality in microscopic polyangiitis: multicentre REVEAL cohort study. Arthritis Res Ther. Published 20 November 2023. doi:10.
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