Vasculitis & polymyalgia rheumatica
A microRNA sponge, LINC02193, promotes neutrophil activation by upregulating ICAM1 and is correlated with ANCA-associated vasculitis
Authors' conclusion
LINC02193, a novel lncRNA identified in AAV, could function as competing endogenous RNAs for miR-485-5p to promote ICAM1 expression and neutrophils activation
Study context
- Population
- ANCA-associated vasculitis (AAV) patients, healthy controls and disease controls; peripheral leukocytes and neutrophilsRNA-sequencing (RNA-seq) 5 AAV, 5 healthy controls (HC)
- Comparison
- AAV patients vs healthy controls and disease controls; LINC02193 knockdown in differentiated HL-60 cells
- Disease controlsn = 64
- Outcome
- LncRNA expression and LINC02193 function in AAV
Methodological detailsRNA-seq screening, qRT-PCR validation, loss-of-function study, dual luciferase reporter and RNA immunoprecipitation assays
- RNA-seq screening
- qRT-PCR validation
- Loss-of-function study
- Dual luciferase reporter and RNA immunoprecipitation assays
Main finding
As reported in the abstract
Upregulated long noncoding RNAs (lncRNAs) in AAV patients
467
Downregulated lncRNAs in AAV patients
412
Original publication
A microRNA sponge, LINC02193, promotes neutrophil activation by upregulating ICAM1 and is correlated with ANCA-associated vasculitis. Rheumatology (Oxford). Published 14 November 2023. doi:10.
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