Vasculitis & polymyalgia rheumatica
Burden of coronary artery calcification in ANCA-associated vasculitis
Authors' conclusion
A majority of patients with AAV had clinically significant CAC. There were differences in CAC burden among those with MPO-ANCA+AAV versus PR3-ANCA+AAV.
Study context
- Population
- Patients in the 2002–2019 Mass General Brigham ANCA-associated vasculitis (AAV) cohort with thoracic CT scans obtained for other clinical purposes
- Participants
- 175 patients
- Exposure
- MPO-ANCA+ AAV vs PR3-ANCA+ AAV
- MPO-ANCA+n = 127
- PR3-ANCA+n = 48reference
- Outcome
- CAC scores and age, sex and race-standardised CAC percentiles
Methodological detailsquantile regression, Gray's test
- Quantile regression
- Gray's test
Main finding
As reported in the abstract
CAC burden
Median coronary artery calcium (CAC) score (IQR 0, 334)
17
Median CAC percentile (IQR 0, 78)
45
CAC ≥100, n (%)
65
39%
Observational data: associations, not effects.
Further findings
| Outcome | MPO-ANCA+ | PR3-ANCA+ | P value |
|---|---|---|---|
| Total CAC score by ANCA typeMedian | 24 | 1 | P = 0.003 |
| Standardised CAC percentile by ANCA type | 50th | 34th | P = 0.02 |
Statin use among patients with non-zero CAC (n=116, 66%)
- On a statin
- 29 (25%)
MACE by CAC ≥100 (time-to-event)
- CAC ≥100 trended towards higher MACE risk (χ2=1.9)
- P = 0.16
Original publication
Burden of coronary artery calcification in ANCA-associated vasculitis. RMD Open. Published 6 January 2025. doi:10.
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