Vasculitis & polymyalgia rheumatica
Interstitial lung disease in ANCA-associated vasculitis: associated factors, radiographic features and mortality
Main finding · All-cause mortalityResult — go to the resultAdjusted hazard ratio 1.58 95% CI 1.06–2.37Authors' conclusion
ILD is a frequent complication of AAV, especially MPO-ANCA+ AAV, often preceding recognition of AAV. Fibrotic AAV-ILD is associated with a higher risk of death than AAV without ILD.
Study context
- Population
- PR3- or MPO-ANCA+ ANCA-associated Vasculitis (AAV) patients, 2002–2019 Mass General Brigham AAV Cohort, United StatesMGB AAV Cohort
- Participants
- 684 participants
- Exposure
- AAV with interstitial lung disease (ILD) vs AAV without ILD
- AAV-ILDn = 91
- Outcome
- Prevalence of ILD in AAV and association of AAV-ILD with all-cause mortality
Methodological detailsconsecutive inception cohort, Cox proportional hazard models with age as the time scale, radiologist-confirmed ILD
- Consecutive inception cohort
- Cox proportional hazard models with age as the time scale
- Radiologist-confirmed ILD
Main finding
All-cause mortality
Adjusted hazard ratio
1.58
95% CI 1.06–2.37
Events by group
AAV-ILD
13%
91
Fibrotic AAV-ILDvs Without ILD
aHR 1.58 (95% CI 1.06–2.37)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Age at AAV diagnosis
P < 0.001
MPO-ANCA+
P < 0.001
Age at AAV diagnosis
- Distribution of sex and race similar
ILD prevalence among MPO-ANCA+ patients (n = 470) (subgroup)
- Had ILD
- 85 (18%)
ILD radiographic features
- Fibrotic ILD
- 76%
- UIP pattern (most common)
- 42%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Interstitial lung disease in ANCA-associated vasculitis: associated factors, radiographic features and mortality. Rheumatology (Oxford). Published 14 June 2022. doi:10.
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