Vasculitis & polymyalgia rheumatica
Circulating PD-1hi CXCR5– and CXCR5+ CD4 T cells are elevated in patients with newly diagnosed giant cell arteritis, and predict relapse
Authors' conclusion
nGCA patients demonstrate increased baseline cTph and cTfh cell frequencies. Lower baseline proportions of cTph and cTfh cells associate with relapse.
Study context
- Population
- Consecutive patients with newly diagnosed GCA referred to a US GCA fast-track clinic over 24 months65 nGCA patients
- Exposure
- Newly diagnosed GCA vs age- and gender-matched healthy controls
- nGCAn = 65
- Outcome
- Frequency of circulating Tph (cTph) and Tfh (cTfh) cells
- Follow-up
- Baseline
Methodological detailsnon-interventional, consecutive patients, age- and gender-matched healthy controls
- Non-interventional
- Consecutive patients
- Age- and gender-matched healthy controls
Main finding
As reported in the abstract
Frequency of cTph and cTfh cells
- Increased frequency of circulating Tph (cTph) and cTfh cells in nGCA vs healthy control (HC)
Observational data: associations, not effects.
Further findings
Relapse within 12 months
- Patients followed up for 12 months
- 46
- Patients who relapsed
- 19
- Baseline cTph and cTfh frequency significantly lower in patients who relapsed vs those who did not
cTph cell frequency <1.0 predicting relapse · 12 months
- Sensitivity
- 90%
- Specificity
- 93%
Original publication
Circulating PD-1hi CXCR5– and CXCR5+ CD4 T cells are elevated in patients with newly diagnosed giant cell arteritis, and predict relapse. Rheumatology (Oxford). Published 3 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →