Vasculitis & polymyalgia rheumatica
Age, anticoagulants, hypertension and cardiovascular genetic traits predict cranial ischaemic complications in patients with giant cell arteritis
Authors' conclusion
Age and hypertension were risk factors for cranial ischaemic complications at GCA presentation, but in this dataset, anticoagulation appeared protective.
Study context
- Population
- Patients with giant cell arteritis (GCA) with clinicodemographic data at GCA presentation (median age=71, 68.7% female)
- Participants
- 1,946 patients
- Exposure
- Pre-existing cardiovascular (CV)-related traits (incl. Polygenic Risk Scores (PRS) for CV traits) vs cranial ischaemic complications at GCA presentation
- Outcome
- Cranial ischaemic complications at GCA presentation
- Follow-up
- GCA presentation
Methodological detailselastic net model optimisation, polygenic risk scores, positional gene mapping
- Elastic net model optimisation
- Polygenic risk scores
- Positional gene mapping
Main finding
As reported in the abstract
Cranial ischaemic complications at presentation (multivariable analysis)
Adjusted odds ratio (95% CI)P value
Anticoagulant therapy
0.21(0.05–0.62)
P = 4.95×10-3Age ≥80 yearsvs Age <60 years
1.60(0.73–3.66)
P = 2.52×10-3- Proportion with cranial ischaemic complications at presentation
- 17%
- Variables associated with complications in univariable analyses (likelihood-ratio test p≤0.05)
- 10
Observational data: associations, not effects.
Further findings
Hypertension and cranial ischaemic complications (sensitivity analysis omitting anticoagulant therapy) · GCA presentation
| aOR (95% CI) | P value | ||
|---|---|---|---|
| HypertensionSensitivity analysis omitting anticoagulant therapy | 1.35 (1.03–1.75) | P = 0.03 | |
| 0.512Adjusted odds ratio (log scale) |
- Age and hypertension associated with complications
Positional gene mapping of associated transient ischaemic attack PRS
- TEK, CD96 and MROH9 loci identified
Original publication
Age, anticoagulants, hypertension and cardiovascular genetic traits predict cranial ischaemic complications in patients with giant cell arteritis. Ann Rheum Dis. Published 2 January 2025. doi:10.
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