Vasculitis & polymyalgia rheumatica
Different giant cell arteritis phenotypes may present distinct types of ischaemic complications
Authors' conclusion
The subtype of vascular US presentation influences the IC in GCA. US cranial-GCA patients more frequently present AION, while predominantly US LV-GCA more frequently exhibit non-AION IC.
Study context
- Population
- Clinically confirmed giant cell arteritis (GCA) patients referred to ultrasound (US) fast-track clinics at two centres; baseline US of cranial and extracranial arteries43 (22.9%) with ischaemic complications (IC)
- Participants
- 188 participants
- Exposure
- Anterior ischaemic optic neuropathy (AION) vs non-AION IC vs no IC: US phenotype
- AIONn = 24
- Non-AION ICn = 19
- Outcome
- Association of US presentation subtype with type of ischaemic complications (AION or non-AION pattern)
- Follow-up
- At diagnosis and in the following 3 months
Methodological detailsobservational, two centres, US fast-track clinics
- Observational
- Two centres
- US fast-track clinics
Main finding
As reported in the abstract
Ischaemic complications (IC)
Observational data: associations, not effects.
Further findings
US cranial involvement · baseline — AION vs Non-AION IC · three-group comparison incl. without IC
P = 0.009
US LV-GCA signs · baseline — AION vs Non-AION IC · three-group comparison incl. without IC
P = 0.014
AION by polymyalgia rheumatica (PMR) status
- Previous PMR: less frequent AION
- P = 0.049
- Concomitant PMR symptoms at diagnosis: less frequent AION
- P = 0.014
Original publication
Different giant cell arteritis phenotypes may present distinct types of ischaemic complications. Clin Exp Rheumatol. Published 21 May 2024. doi:10.
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