Vasculitis & polymyalgia rheumatica
Granzyme B producing regulatory B-cells in patients with giant cell arteritis
Authors' conclusion
Regulatory B-cells were differentially altered in patients with GCA. While GrB producing Breg were persistently diminished, IL-10 producing Breg showed no differences between patients and controls.
Study context
- Population
- Patients with giant cell arteritis (GCA) and healthy controls; Peripheral blood mononuclear cells (PBMC) assessed for granzyme B (GrB) and IL-10 production of regulatory B-cells
- Participants
- 47 vs 49
- Comparison
- GCA patients vs healthy controls
- GCAn = 47
- Healthy controls (HC)n = 49reference
- Outcome
- GrB and IL-10 production of regulatory B-cells (Breg) after in vitro stimulation
Methodological detailsin vitro stimulation of PBMC
- In vitro stimulation of PBMC
Main finding
As reported in the abstract
Regulatory B-cells
- Fraction of GrB producing Breg diminished in GCA vs HC, independent of current disease activity
- No significant differences between GCA and HC in IL-10 producing Breg
Further findings
- In active GCA, CD4+ T-cells produced less IFNγ than HC
- Trend towards lower expression of other T-cell derived pro-inflammatory cytokines vs HC
Original publication
Granzyme B producing regulatory B-cells in patients with giant cell arteritis. Clin Exp Rheumatol. Published 21 May 2024. doi:10.
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