Vasculitis & polymyalgia rheumatica
Variability in phenotype clusters of Behçet’s syndrome: A systematic review
Authors' conclusion
There is important variability in the phenotype clusters that are reported in different studies and this variability seems to stem from methodologic differences between the studies.
Study context
- Population
- Studies that assessed phenotype clusters in BD cohorts
- Participants
- 15 studies17 cohorts
- Outcome
- Variability in clinical phenotype clustering across different countries and cohorts and possible reasons
Methodological detailsPubMed, EMBASE and Cochrane Library search, two independent reviewers
- PubMed, EMBASE and Cochrane Library search
- Two independent reviewers
Pooled result
As reported in the abstract
Variability in phenotype clusters
- Several differences in the clusters reported across cohorts
- Possible causes: study design, statistical method (hierarchical cluster analysis vs factor analysis), population (paediatric vs adult), setting, diagnostic/classification criteria (International Study Group vs International Criteria for Behçet's Disease), disease duration, definition of organ involvement, ascertainment of manifestations, time component for clustering
Original publication
Variability in phenotype clusters of Behçet’s syndrome: A systematic review. Semin Arthritis Rheum. Published 8 May 2025. doi:10.
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