Vasculitis & polymyalgia rheumatica
Tracheobronchial stenosis in patients with granulomatosis with polyangiitis: histopathological findings and long-term outcome
Authors' conclusion
The majority of patients with GPA and TBS experience recurring airway stenoses. GPA-characteristic findings are seen in approximately one in five tracheobronchial biopsies obtained from GPA patients with TBS.
Study context
- Population
- Patients with granulomatosis with polyangiitis (GPA) and tracheobronchial stenosis (TBS); local cohort diagnosed 1991–2022local cohort
- Participants
- 27 patients
- Outcome
- Histopathological findings (GPA-characteristic vs non-specific) and long-term outcomes, incl. number of endoscopic dilations
Methodological detailslocal cohort, PubMed search until May 2023
- Local cohort
- PubMed search until May 2023
Main finding
As reported in the abstract
Tracheobronchial biopsies with GPA-characteristic findings
- Local cohort: biopsies with GPA-characteristic findings (of 67 biopsies from 26 patients)
- 15 (22%)
- Literature: biopsies with GPA-characteristic findings (of 296 biopsies in 128 of 203 patients)
- 64 (22%)
- Local cohort: patients with ≥1 endoscopic dilation
- 23
- Local cohort: number of dilations, median (range)
- 5 (1-100)
- Local cohort: patients with ≥2 dilations
- 18
- Local cohort: interval between dilations, median (range), months
- 23 (2-103)
Observational data: associations, not effects.
Further findings
Local cohort characteristics, median (range)
- Age at GPA diagnosis, years
- 31 (14-76)
- Follow-up, years
- 17 (0-31)
- Time from GPA diagnosis to TBS, years
- 2 (0-21)
Literature: patients with biopsies
- Patients identified
- 203
- Patients biopsied
- 128 (63%)
Original publication
Tracheobronchial stenosis in patients with granulomatosis with polyangiitis: histopathological findings and long-term outcome. Clin Exp Rheumatol. Published 7 May 2025. doi:10.
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