Vasculitis & polymyalgia rheumatica
Invisible neuropsychiatric burden in Behçet's disease without central nervous system involvement: a phenotype-based comparison
Authors' conclusion
Neuropsychiatric manifestations represent a substantial burden in BD even in the absence of overt neurological involvement, particularly in mBD with less control of inflammation and regular follow-up. These findings support the need for routine neuropsychiatric evaluation across all BD phenotypes, extending beyond the traditional NBD framework.
Study context
- Population
- Patients with Behçet's disease classified by phenotype, familial mediterranean fever patients and healthy controlspatients with Behçet's disease (BD), plus familial mediterranean fever (FMF) patients (n=37) and healthy controls (n=29)
- Participants
- 152 patients
- Exposure
- BD phenotypes compared with neuro-Behçet's disease (NBD), FMF and healthy controls
- mBDn = 69
- oBDn = 26
- vBDn = 40
- NBDn = 17
- FMFn = 37
- Healthy controls (HC)n = 29
- Outcome
- Any headache
Main finding
As reported in the abstract
- p across groups
- P = 0.012
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| BDI scores (depressive symptoms) | mBD 14 · vBD 13.5 · NBD 11 · FMF 9 · HC 7 |
| Cognitive impairment (MMSE ≤23) | mBD 41.2% · NBD 41.2% · vBD 15.0% · FMF 10.8% · HC 24.1% |
- Beck Depression Inventory (BDI) scores (depressive symptoms) — p across groups
- p=0.005
- Cognitive impairment (Mini-Mental State Examination (MMSE) ≤23) — p across groups
- p=0.001
Migraine-type headache
- Most frequent subtype across groups
Beck Anxiety Inventory (BAI) scores
- Did not differ significantly but tended to be higher in mBD
Original publication
Invisible neuropsychiatric burden in Behçet's disease without central nervous system involvement: a phenotype-based comparison. Clin Exp Rheumatol. Published 26 October 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →