Vasculitis & polymyalgia rheumatica
Clinical characteristics, brain magnetic resonance imaging findings and diagnostic approach of the primary central nervous system vasculitis according to angiographic classification
Authors' conclusion
Diagnostic approach for PCNSV differs concerning the affected vessel size. HR-VWI is a useful imaging modality for the diagnosis of LMVV.
Study context
- Population
- Patients with PCNSV with complete brain magnetic resonance imaging (MRI) protocol and cerebral vascular imaging, Cleveland Clinic prospective CNS vasculopathy Bioregistry
- Participants
- 34 patients
- Comparison
- Large-medium vessel variant vs small vessel variant PCNSV
- Large-medium vessel variant (LMVV)n = 11
- Small vessel variant (SVV)n = 23reference
- Outcome
- Diagnostic accuracy of high-resolution vessel wall image (HR-VWI) and brain biopsy by angiographic classification
Methodological detailsprospective bioregistry, single-centre
- Prospective bioregistry
- Single-centre
Main finding
As reported in the abstract
Strong/concentric vessel wall enhancement on HR-VWI
P < 0.001
Observational data: associations, not effects.
Further findings
Diagnostic accuracy of brain biopsy
P = 0.015
Diagnosed by brain biopsy
P = 0.022
- Meningeal/parenchymal contrast enhancement lesion · more frequent in SVV
- P = 0.006
Original publication
Clinical characteristics, brain magnetic resonance imaging findings and diagnostic approach of the primary central nervous system vasculitis according to angiographic classification. Clin Exp Rheumatol. Published 25 April 2022. doi:10.
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