Vasculitis & polymyalgia rheumatica
Interstitial lung disease in microscopic polyangiitis and granulomatosis with polyangiitis: demographic, clinical, serological and radiological features of an Italian cohort from the Italian Society for Rheumatology
Authors' conclusion
Our study confirms that UIP is a frequent pattern of lung disease in AAVILD patients. Our results also suggest that ILD can represent an early complication of AAV but also occur in the course of the disease
Study context
- Population
- Consecutive patients with AAV-ILD (microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA)), Italian national cohort, Italian Society for RheumatologyAAV-ILD
- Participants
- 95 patients
- Exposure
- MPA vs GPA
- MPAn = 56
- GPAn = 39
- Outcome
- Demographic, clinical and serological profile of ILD related to MPA and GPA, and correlations between radiologic ILD patterns and vasculitis features
Methodological detailsnational, consecutive patients
- National
- Consecutive patients
Main finding
As reported in the abstract
- NSIP most frequent interstitial lung disease (ILD) pattern; in c-ANCA patients
- 60.9%
- UIP pattern, mainly in p-ANCA patients
- 47.7%, p=0.03
- ILD as first clinical manifestation, preceding vasculitis diagnosis
- 22.1%
- ILD already detectable at AAV diagnosis
- 66.3%
- ILD diagnosis preceded AAV in p-ANCA positive patients vs only one c-ANCA patient
- 85.7% vs 1 patient, p= 0.039
Observational data: associations, not effects.
Original publication
Interstitial lung disease in microscopic polyangiitis and granulomatosis with polyangiitis: demographic, clinical, serological and radiological features of an Italian cohort from the Italian Society for Rheumatology. Clin Exp Rheumatol. Published 13 April 2022. doi:10.
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