Vasculitis & polymyalgia rheumatica
The role of tobacco smoking in antineutrophil cytoplasmic antibody-associated vasculitis: a systematic review
Authors' conclusion
Current data support the hypothesis that smoking influences prevalence, clinical phenotype and prognosis of ANCA-associated vasculitis.
Study context
- Population
- Patients with AAV (granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), eosinophilic granulomatosis with polyangiitis (EGPA))26 articles
- Comparison
- Tobacco smoking vs not smoking in AAV
- Outcome
- Role of smoking in the development, clinical presentation and outcome of AAV
Methodological detailsPubMed/Medline and Cochrane Library, English-language articles only, case reports excluded
- PubMed/Medline and Cochrane Library
- English-language articles only
- Case reports excluded
Pooled result
As reported in the abstract
- Role of smoking in AAV development unclear
- Current smokers with AAV appear younger and more often male, with lower prevalence of EGPA and MPA than GPA
- Ever smokers show higher relapse rate
- Smoking seems associated with higher risk of cardiovascular events during follow-up
- Smokers incur increased risk of infections
- Many data support smoking as a risk factor for end stage renal disease and mortality in AAV
Original publication
The role of tobacco smoking in antineutrophil cytoplasmic antibody-associated vasculitis: a systematic review. Clin Exp Rheumatol. Published 12 March 2024. doi:10.
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