Vasculitis & polymyalgia rheumatica
Upper respiratory tract and orofacial manifestations of new-onset giant cell arteritis: results from a large, prospective inception cohort study
Authors' conclusion
Oral-facial symptoms were present in two-thirds of GCS cases.
Study context
- Population
- Patients newly diagnosed with giant cell arteritis (GCA) between 1976 and April 2022 at the Internal Medicine Department of a tertiary-care hospital
- Participants
- 599 patients
- Outcome
- Frequency of URT/orofacial symptoms at GCA onset
- Follow-up
- GCA onset
Methodological detailssingle-centre, tertiary-care hospital, multivariate analyses, Ten upper respiratory tract (URT) or orofacial symptoms prospectively examined systematically in each patient
- Single-centre
- Tertiary-care hospital
- Multivariate analyses
- Ten URT or orofacial symptoms prospectively examined systematically in each patient
Main finding
As reported in the abstract
At least 1 URT/orofacial symptom
At least 1 URT/orofacial symptom
68.6%
3 or more symptoms
30%
Dry cough
17%
Isolated URT/orofacial presentation (without headache or visual signs)
5.2%
Observational data: associations, not effects.
Further findings
Factors associated with positive temporal artery biopsy (TAB) (multivariate)
| OR (CI) | P value | ||
|---|---|---|---|
| Abnormal temporal artery on clinical examination | 4.16 (2.75–6.37) | P < 0.001 | |
| Jaw claudication | 2.18 (1.35–3.65) | P = 0.002 | |
| Hoarseness | 0.47 (0.26–0.87) | P = 0.02 | |
| Earache | 0.54 (0.31–0.95) | P = 0.03 | |
| 0.10.31310Odds ratio (log scale) |
Characteristics of patients with URT/orofacial symptoms
- More clinical abnormalities of the temporal artery bed and ischaemic ophthalmological complications, but less large-vessel vasculitis on imaging
Original publication
Upper respiratory tract and orofacial manifestations of new-onset giant cell arteritis: results from a large, prospective inception cohort study. Clin Exp Rheumatol. Published 7 March 2024. doi:10.
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