Vasculitis & polymyalgia rheumatica
Cognitive impairment and other neuropsychiatric manifestations in patients with primary vasculitis: a systematic review
Authors' conclusion
Cognitive impairment and other neuropsychiatric manifestations are commonly reported in vasculitis
Study context
- Population
- Patients with primary vasculitis (PCNSV, ANCA-associated vasculitis (AAV), giant cell arteritis (GCA), TAK, polyarteritis nodosa (PAN), Behçet's disease (BD), other types); ages 7.1–75.6 years, 11–100 % female43 studies
- Participants
- 750 / 433 / 157 / 12 / 486
- Comparison
- Adult-onset PCNSV vs Childhood-onset PCNSV vs AAV vs GCA vs Other vasculitis
- Adult-onset PCNSVn = 750
- Childhood-onset PCNSVn = 433
- AAVn = 157
- GCAn = 12
- Other vasculitisn = 486
- Outcome
- Cognitive impairment
Methodological detailsNewcastle Ottawa Scale quality assessment, Most included studies single-center retrospective, good or fair quality
- Newcastle Ottawa Scale quality assessment
- Most included studies single-center retrospective, good or fair quality
Pooled result
As reported in the abstract
Adult-onset PCNSV
11-62 %
275 of 750
Childhood-onset PCNSV
10-54 %
126 of 433
AAV
12-61 %
62 of 157
GCA
20-43 %
4 of 12
Other vasculitis
20-67 %
261 of 486
Further pooled results
Standardized neuropsychological testing done
- Studies using standardized neuropsychological testing
- 12/43 (28 %)
Factors associated with neuropsychiatric manifestations (minority of studies)
- Associations with MRI abnormalities and with worse prognosis and/or higher disease activity
Response to immunosuppressive therapy
- Most patients improved but had residual neuropsychiatric symptoms
Original publication
Cognitive impairment and other neuropsychiatric manifestations in patients with primary vasculitis: a systematic review. Semin Arthritis Rheum. Published 5 August 2025. doi:10.
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