Vasculitis & polymyalgia rheumatica
Brain white matter microstructural alterations in Behcet's syndrome correlate with cognitive impairment and disease severity: A diffusion tensor imaging study
Authors' conclusion
DTI findings might potentially serve as a neuroimaging marker to predict the extent of neurocognitive impairment and disease severity associated with central nervous system involvement in BS.
Study context
- Population
- Patients with Neuro-Behcet's syndrome and Behcet's syndrome without neurological manifestations, and healthy controls
- Participants
- 34 / 32 / 33
- Exposure
- Neuro-Behcet's syndrome vs Behcet's syndrome without neurological manifestations vs healthy controls
- Neuro-Behcet's syndrome (NBS)n = 34
- Behcet's syndrome (BS)n = 32
- Healthy controlsn = 33reference
- Outcome
- Microstructural integrity of brain white matter tracts on diffusion tensor imaging (DTI)
Methodological detailsdiffusion tensor imaging, tract-based spatial statistics, automated probabilistic tractography
- Diffusion tensor imaging
- Tract-based spatial statistics
- Automated probabilistic tractography
Main finding
As reported in the abstract
White matter microstructural integrity (DTI)
- NBS: decreased fractional anisotropy and increased radial, mean and axial diffusivity in supratentorial and infratentorial white matter, indicating widespread loss of microstructural integrity
- BS without neurological manifestations: loss of integrity also observed, to a lesser extent
Observational data: associations, not effects.
Further findings
Association of white matter tracts with cognition and disease severity in NBS
- Certain tracts, including cingulum bundle, associated with poor cognitive performance across multiple domains and disease severity
Original publication
Brain white matter microstructural alterations in Behcet's syndrome correlate with cognitive impairment and disease severity: A diffusion tensor imaging study. Semin Arthritis Rheum. Published 2 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →