Vasculitis & polymyalgia rheumatica
Polymyalgia rheumatica is a risk factor for more recalcitrant disease in giant cell arteritis: A retrospective cohort study
Main finding · RelapseResult — go to the resultHazard ratio 1.38 95% CI 1.06–1.79Authors' conclusion
GCA patients with PMR symptoms had more recalcitrant disease with a higher risk of relapse and longer duration of GC treatment with need for higher GC doses.
Study context
- Population
- Consecutive patients diagnosed with giant cell arteritis (GCA) 2000–2020 and followed ≥12 months, University Hospitals Leuven (Belgium)
- Participants
- 398 patients
- Exposure
- GCA with PMR symptoms vs GCA without PMR symptoms
- Outcome
- Relapse
Methodological detailssingle-centre, consecutive patients
- Single-centre
- Consecutive patients
Main finding
As reported in the abstract
Hazard ratio
1.38
95% CI 1.06–1.79
P = 0.017
By group
PMR symptomsvs No PMR symptoms
HR 1.38 (95% CI 1.06–1.79); P = 0.017
Observational data: associations, not effects.
Further findings
| Outcome | Values | HR (95% CI) | P value | |
|---|---|---|---|---|
| Stopping GCPMR symptomsvs No PMR symptoms | PMR symptoms 62% · No PMR symptoms 71% | 0.74 (0.58–0.94) | P = 0.018 | |
| 0.512Hazard ratio (log scale) |
| Outcome | Values | P value |
|---|---|---|
| Symptom durationPMR symptoms vs No PMR symptoms | PMR symptoms 11 weeks · No PMR symptoms 6 weeks | P < 0.001 |
| FeverPMR symptoms vs No PMR symptoms | P = 0.030 | |
| FatiguePMR symptoms vs No PMR symptoms | No PMR symptoms 64% | P = 0.015 |
| Cumulative oral GC dose at 2 yearsPMR symptoms vs No PMR symptoms | P = 0.571 | |
| Median duration of GC treatmentPMR symptoms vs No PMR symptoms | PMR symptoms median 29 months · No PMR symptoms median 23 months | P = 0.021 |
| Thoracic aortic aneurysm during follow-upPMR symptoms vs No PMR symptoms | P = 0.005 |
Cumulative oral GC dose at 2 years
- No difference in cumulative oral GC dose at 2 years (4.4 vs 4.3 g methylprednisolone)
Relapse
- Relapse rate, PMR symptoms vs none: 64% vs 51%
Thoracic aortic aneurysm during follow-up
- Thoracic aortic aneurysms, PMR symptoms vs none: 3% vs 11%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Polymyalgia rheumatica is a risk factor for more recalcitrant disease in giant cell arteritis: A retrospective cohort study. Semin Arthritis Rheum. Published 28 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →