Vasculitis & polymyalgia rheumatica
Validation of the polymyalgia rheumatica-activity score: A prospective cohort study
Authors' conclusion
PMR-AS had a good discriminatory capacity for detecting active disease, but the alternative PMR-AS performed slightly better.
Study context
- Population
- PMR patients, University Hospitals Leuven (Belgium), July 2022–December 2023
- Participants
- 133 patients419 visits
- Exposure
- Polymyalgia rheumatica-activity score (PMR-AS) vs change in PMR-AS and alternative activity scores for detecting active disease
- Outcome
- Discriminatory capacity (AUC) for detecting active disease
Methodological detailssingle-centre, GEE-logistic prediction models for repeated measures, Delong's tests
- Single-centre
- GEE-logistic prediction models for repeated measures
- Delong's tests
Main finding
As reported in the abstract
Discriminatory capacity for detecting active disease
| Group | AUC | Optimal cut-off | Sensitivity | Specificity |
|---|---|---|---|---|
| PMR-AS | 0.938 | 11.0 | 87 % | 87 % |
| Change in PMR-AS | 0.862 | |||
| Clinical-PMR-AS | 0.928 | |||
| Imputed-PMR-AS | 0.928 | |||
| ESR-PMR-AS | 0.932 | |||
| Alternative PMR-AS | 0.948 | 13.5 | 87 % | 88 % |
AUC
PMR-AS0.938
Change in PMR-AS0.862
Clinical-PMR-AS0.928
Imputed-PMR-AS0.928
ESR-PMR-AS0.932
Alternative PMR-AS0.948
Optimal cut-off
PMR-AS11.0
Change in PMR-AS— not stated in the abstract
Clinical-PMR-AS— not stated in the abstract
Imputed-PMR-AS— not stated in the abstract
ESR-PMR-AS— not stated in the abstract
Alternative PMR-AS13.5
Sensitivity
PMR-AS87 %
Change in PMR-AS— not stated in the abstract
Clinical-PMR-AS— not stated in the abstract
Imputed-PMR-AS— not stated in the abstract
ESR-PMR-AS— not stated in the abstract
Alternative PMR-AS87 %
Specificity
PMR-AS87 %
Change in PMR-AS— not stated in the abstract
Clinical-PMR-AS— not stated in the abstract
Imputed-PMR-AS— not stated in the abstract
ESR-PMR-AS— not stated in the abstract
Alternative PMR-AS88 %
- Change in PMR-AS vs PMR-AS: all p≤0.010 — significantly worse; p shared with Clinical-PMR-AS and Imputed-PMR-AS
- Clinical-PMR-AS vs PMR-AS: all p≤0.010 — significantly worse
- Imputed-PMR-AS vs PMR-AS: all p≤0.010 — significantly worse
- ESR-PMR-AS vs PMR-AS: P = 0.050 — tended to be lower
- Alternative PMR-AS vs PMR-AS: P = 0.010 — higher AUC
Observational data: associations, not effects.
Original publication
Validation of the polymyalgia rheumatica-activity score: A prospective cohort study. Semin Arthritis Rheum. Published 23 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →