Vasculitis & polymyalgia rheumatica
Assessment of damage in Takayasu’s arteritis
Authors' conclusion
Damage is present in >80% of patients with TAK even with recent diagnosis and >40% of patients accrue new, mainly disease-specific damage.
Study context
- Population
- Patients with TAK in a multicentre prospective observational study (92% female, 81% Caucasian; median disease duration 2.6 years)84% had follow-up
- Participants
- 236 patients
- Outcome
- Damage assessed by VDI and LVVID, and clinical characteristics associated with damage
Methodological detailsmulticentre, standardized damage assessment every 6 months (Vasculitis Damage Index (VDI) and Large-Vessel Vasculitis Index of Damage (LVVID))
- Multicentre
- Standardized damage assessment every 6 months (VDI and LVVID)
Main finding
As reported in the abstract
Items of damage present
- Any damage, VDI
- 89%
- Any damage, LVVID
- 87%
- Peripheral vascular damage, VDI
- 76%
- Peripheral vascular damage, LVVID
- 74%
- Cardiac damage, VDI
- 40%
- Cardiac damage, LVVID
- 45%
Observational data: associations, not effects.
Further findings
New damage during follow-up · median follow-up 4.1 (1.9, 7.5) years
- Patients with new damage
- 42%
- Major vessel stenosis/arterial occlusion
- 8%
- Limb claudication
- 6%
- Hypertension
- 7%
- Aortic aneurysm
- 4%
- Bypass surgery
- 4%
- Disease-specific damage share of new items
- >90%
Factors associated with new damage
- Higher proportion of patients without new damage on MTX
- P < 0.05
- Older age, relapse and longer follow-up associated with new damage items
- History of relapse associated with new damage in entire cohort; older age at diagnosis in recently diagnosed
New damage in patients diagnosed within 180 days of enrolment (subgroup, n=48)
- New damage, VDI
- 31%
- New damage, LVVID
- 52%
Original publication
Assessment of damage in Takayasu’s arteritis. Rheumatology (Oxford). Published 17 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →