Vasculitis & polymyalgia rheumatica
Identification of two autoantigens recognised by circulating autoantibodies as potential biomarkers for diagnosing giant cell arteritis
Authors' conclusion
Detecting GCA-specific autoantibodies may offer a new, non-invasive tool for improving our diagnostic power in GCA.
Study context
- Population
- Patients with giant cell arteritis (GCA), Takayasu and healthy controls
- Participants
- 55 / 7 / 28
- Comparison
- Sera from patients with GCA vs TAK vs healthy controls
- GCAn = 55
- TAKn = 7
- HCn = 28reference
- Outcome
- Serum autoantibodies as new diagnostic biomarkers for GCA
Methodological detailshuman protein array, ELISA, One commercial and one proprietary human protein array used for antibody profiling; candidate autoantigens purified and tested by ELISA
- Human protein array
- ELISA
- One commercial and one proprietary human protein array used for antibody profiling; candidate autoantigens purified and tested by ELISA
Performance
As reported in the abstract
Autoantibodies against VSIG10L and DCBLD1
| Test or model | Value | Overall prevalence (VSIG10L and DCBLD1, respectively) |
|---|---|---|
| GCA | 43-57% | 43-57% |
GCA
Value43-57%
Overall prevalence (VSIG10L and DCBLD1, respectively)43-57%
Original publication
Identification of two autoantigens recognised by circulating autoantibodies as potential biomarkers for diagnosing giant cell arteritis. Clin Exp Rheumatol. Published 17 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →