Vasculitis & polymyalgia rheumatica
Carotid vasa vasorum detected by super-resolution ultrasound microvascular imaging in Takayasu's arteritis: a potential biomarker of disease activity and early treatment outcome
Authors' conclusion
SRUS detection of carotid vasa vasorum serves as a useful indicator for assessing the activity and severity of TAK.
Study context
- Population
- Patients with TAK (26 active, 44 inactive per 1990 ACR criteria), November 2023 to July 202426 active, 44 inactive
- Participants
- 70 patients
- Comparison
- Super-resolution ultrasound (SRUS)-detected carotid vasa vasorum present vs absent for TAK activity
- With vasa vasorumn = 14
- Without vasa vasorumn = 56reference
- Outcome
- Diagnostic performance of SRUS-detected carotid vasa vasorum for TAK disease activity
Methodological detailsconsecutive inclusion, prospective follow-up with Kaplan-Meier analysis
- Consecutive inclusion
- Prospective follow-up with Kaplan-Meier analysis
Performance
As reported in the abstract
Vasa vasorum presence for active TAK
| Test or model | Value | Sensitivity | Specificity | Accuracy |
|---|---|---|---|---|
| Vasa vasorum present | 14 events | 42.3% | 93.2% | 74.3% |
Vasa vasorum present
Value14 events
Sensitivity42.3%
Specificity93.2%
Accuracy74.3%
- Presence of vasa vasorum correlated strongly with disease activity
- P < 0.001
Further findings
Remission among patients with active TAK, by carotid vasa vasorum · mean 8.7±2.7 months follow-up
P = 0.036
- Remission among patients with active TAK, by carotid vasa vasorum: 41 patients completed follow-up (17 active, 24 inactive)
Prediction model (clinical and ultrasound (US) characteristics) for TAK activity
- AUC
- 0.900
Relapse among patients with inactive TAK · mean 8.7±2.7 months follow-up
- Inactive TAK maintained stable disease; relapsed to active phase
- 1
Original publication
Carotid vasa vasorum detected by super-resolution ultrasound microvascular imaging in Takayasu's arteritis: a potential biomarker of disease activity and early treatment outcome. Clin Exp Rheumatol. Published 20 July 2025. doi:10.
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