Vasculitis & polymyalgia rheumatica
AYLo study–elevated relapse risk and dysregulated proinflammatory signalling in giant cell arteritis patients with mosaic loss of the Y chromosome
Authors' conclusion
This study is the first to identify mLOY as a strong, independent predictor of relapse risk and to link mLOY with modulated proinflammatory signalling in GCA.
Study context
- Population
- Patients diagnosed with giant cell arteritis (GCA), prospectively recruited (mean age 76.0 years, SD 10.7)19/74 active disease at inclusion
- Participants
- 74 patients
- Exposure
- mLOY >10.2% vs mLOY ≤10.2%
- Outcome
- Prevalence of mLOY in GCA and its impact on disease activity (relapse)
Methodological detailsprospective recruitment, ROC curve and Youden index threshold, Kaplan-Meier analysis with log-rank test, multivariable Cox regression
- Prospective recruitment
- ROC curve and Youden index threshold
- Kaplan-Meier analysis with log-rank test
- Multivariable Cox regression
Main finding
Relapse
Hazard ratio
17.4
95% CI 3.5–86.0
P = 0.003
By group
mLOY >10.2%vs mLOY ≤10.2%
HR 17.4 (95% CI 3.5–86.0); P = 0.003
As reported in the abstract
- Relapses occurred in the cohort
- 23.0%
- Median mLOY burden (SD 23.7%)
- 17.8%
- Optimal threshold for predicting relapse
- 10.2%
Observational data: associations, not effects.
Further findings
mLOY and IL-6 across the cohort
- mLOY positively associated with IL-6, r = 0.24
- P = 0.045
- Elevated IL-6 in remission patients with mLOY >10.2%
- P = 0.010
mLOY and cytokines in patients on IL-6R inhibitor and in remission
- mLOY positively associated with IL-6, r = 0.54
- P = 0.002
- mLOY positively associated with IL-17A, r = 0.40
- P = 0.026
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
AYLo study–elevated relapse risk and dysregulated proinflammatory signalling in giant cell arteritis patients with mosaic loss of the Y chromosome. Ann Rheum Dis. Published 15 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →