Vasculitis & polymyalgia rheumatica
Primary central nervous system vasculitis with intracranial aneurysm
Authors' conclusion
UIAs uncommonly occur in PCNSV.
Study context
- Population
- Consecutive patients with primary central nervous system vasculitis (PCNSV) selected by predetermined diagnostic criteria, seen during a 40-year period
- Participants
- 216 patients
- Exposure
- PCNSV with UIA vs PCNSV without UIA
- UIAn = 12
- Without UIAn = 204reference
- Outcome
- Occurrence of UIA in PCNSV
Methodological detailsconsecutive patients, 40-year period
- Consecutive patients
- 40-year period
Main finding
As reported in the abstract
PCNSV patients with at least one UIA
UIA
5.5 %
12
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Disability at last follow-up | P = 0.038 |
- Disability at last follow-up: reduced disability with UIA; no other significant clinical differences
Presenting symptoms in PCNSV with UIA
%
- Headache
- 67
- Persistent neurologic deficit or stroke
- 50
- Multiple cerebral infarcts on MRI
- 67
UIA location
%
- Internal carotid artery
- 50
- Anterior cerebral artery
- 21
UIA size
- Unruptured intracranial aneurysms (UIAs) < 5 mm in diameter
- 10
- UIAs 5-7 mm in diameter
- 3
- Size not available
- 1
UIA change during follow-up · median: 18.5 months; range 1-151 months
- All UIAs unchanged in size and configuration; no new aneurysms detected
Original publication
Primary central nervous system vasculitis with intracranial aneurysm. Semin Arthritis Rheum. Published 29 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →