Vasculitis & polymyalgia rheumatica
Baseline features and functional outcomes in primary central nervous system vasculitis: development and validation of a prognostic model
Authors' conclusion
Baseline clinical and imaging variables may predict 12-month functional independence in adults with PCNSV.
Study context
- Population
- Adults with primary central nervous system vasculitis (PCNSV), COVAC' cohort (mean age 48 years; 41% female)67 (33%) biopsy-diagnosed
- Participants
- 206 adults
- Outcome
- Functional independence (modified Rankin Scale 0-2) after start of corticosteroids or immunosuppressants
- Follow-up
- 12 months
Methodological detailsmulticentre, international cohort, external validation in single-centre cohort from India, multivariable analyses, AUC-ROC
- Multicentre, international cohort
- External validation in single-centre cohort from India
- Multivariable analyses
- AUC-ROC
Performance
As reported in the abstract
Functional independence (mRS 0-2) and baseline prognostic factors
- Functionally independent at 12 months
- 135 (66%)
- ≥1 intracranial stenosis on CT- or MR-angiogram (favourable), OR
- 2.99 (1.23-7.68) (95% CI)
- Headache (favourable), OR
- 2.67 (1.31-5.59) (95% CI)
- Altered level of consciousness (unfavourable), OR
- 0.09 (0.02-0.31) (95% CI)
- ≥1 acute brain infarct (unfavourable), OR
- 0.12 (0.04-0.33) (95% CI)
- Cognitive impairment (unfavourable), OR
- 0.22 (0.10-0.46) (95% CI)
- Five-variable model AUC, derivation cohort
- 0.80 (0.74-0.87) (95% CI)
- Five-variable model AUC, validation cohort
- 0.67 (0.54-0.81) (95% CI)
Further findings
Death · 12 months
- Died
- 12 (6%)
Original publication
Baseline features and functional outcomes in primary central nervous system vasculitis: development and validation of a prognostic model. Rheumatology (Oxford). Published 10 November 2025. doi:10.
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