Vasculitis & polymyalgia rheumatica
Incidence of ANCA-associated vasculitis and polyarteritis nodosa in Norfolk, UK, from 2011 to 2020
Authors' conclusion
The incidence of AAV, specifically that of granulomatosis with polyangiitis and of microscopic polyangiitis, is slowly rising over time. It is most notable among the elderly population, among whom the incidence rates for granulomatosis with polyangiitis and microscopic polyangiitis peak.
Study context
- Population
- Adults newly diagnosed with AAV or PAN, 2011–2020, residing in postal areas NR1-NR30, Norfolk County, UK
- Participants
- 164 adults4.7 million person-years
- Outcome
- Annual and age-specific incidence of AAV and PAN
Methodological detailsEuropean Medicines Agency classification algorithm
- European Medicines Agency classification algorithm
Main finding
As reported in the abstract
Annual incidence (per million person-years)
- AAV
- 34.3 (95% CI 29.2, 40)/million person-years
- GPA
- 18.9 (95% CI 15.2, 23.3)/million person-years
- MPA
- 12.8 (95% CI 9.7, 16.4)/million person-years
- EGPA
- 2.6 (95% CI 1.3, 4.5)/million person-years
- PAN
- 0.6 (95% CI 0.1, 1.9)/million person-years
Observational data: associations, not effects.
Further findings
Peak age-specific incidence (rose with each decade of life)
- GPA, 8th decade
- 53.2 (95% CI 36.2, 75.6) per million
- MPA, 9th decade
- 48.4 (95% CI 27.1, 79.8) per million
Original publication
Incidence of ANCA-associated vasculitis and polyarteritis nodosa in Norfolk, UK, from 2011 to 2020. Rheumatology (Oxford). Published 30 January 2025. doi:10.
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