Vasculitis & polymyalgia rheumatica
Incidence of primary large vessel vasculitis in Norfolk, UK from 2011 to 2020
Authors' conclusion
This is the first study that reports the incidence of objectively verified primary LVV in the adult population. The incidence of GCA may be affected by the availability of diagnostic pathways. The use of the 2022 classification criteria results in a rise in the classification of GCA and fall in that of TAK.
Study context
- Population
- Adult population of Norfolk County, UK (NR1-NR30 postcode districts); individuals with primary large vessel vasculitis (LVV) diagnosed by histology or imaging, including giant cell arteritis (GCA) (≥50 years) and TAK
- Participants
- 270 participants4.7 million person-years
- Outcome
- Annual incidence of primary LVV, including GCA (≥50 years) and TAK
Methodological detailshistology- or imaging-verified diagnosis, 1990 and 2022 classification criteria
- Histology- or imaging-verified diagnosis
- 1990 and 2022 classification criteria
Main finding
As reported in the abstract
Annual incidence of primary LVV, adult population
Primary LVV incidence
57.5 (50.8, 64.7)/million person-years (95% CI)
Observational data: associations, not effects.
Further findings
Annual incidence of GCA, aged ≥50 years
- GCA, 1990 criteria: 227 individuals; incidence
- 91.6 (80.0, 104.3)/million person-years (95% CI)
- GCA, 2022 criteria: 244 individuals; incidence
- 98.4 (86.4, 111.6)/million person-years (95% CI)
- ≈2.5 million person-years
Annual incidence of TAK, adult population
- TAK, 1990 criteria: 13 individuals; incidence
- 2.8 (1.5, 4.7)/million person-years (95% CI)
- TAK, 2022 criteria: 2 individuals; incidence
- 0.4 (0.0, 1.4)/million person-years (95% CI)
GCA incidence over time
- Rose sharply in 2017 with introduction of a fast-track pathway and fell during the pandemic when the pathway was disrupted
Original publication
Incidence of primary large vessel vasculitis in Norfolk, UK from 2011 to 2020. Ann Rheum Dis. Published 30 June 2023. doi:10.
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