Vasculitis & polymyalgia rheumatica
Indication of Activated Senescence Pathways in the Temporal Arteries of Patients With Giant Cell Arteritis
Authors' conclusion
Our data suggest the presence of activated senescence pathways at the site of vascular inflammation in GCA
Study context
- Population
- Patients with giant cell arteritis (GCA) and age-matched non-GCA individuals who underwent temporal artery biopsy
- Participants
- 8 vs 14
- Comparison
- GCA vs age-matched non-GCA individuals who underwent TAB
- GCAn = 8
- Non-GCAn = 14reference
- Outcome
- Presence of p21+ and p16+ cells producing senescence-associated secretory phenotype (SASP) cytokines (IL-6, GM-CSF) in TABs
Methodological detailsage-matched controls, immunohistochemistry, multiplex immunofluorescence
- Age-matched controls
- Immunohistochemistry
- Multiplex immunofluorescence
Main finding
As reported in the abstract
- Expression of p16, p21, IL-6 and granulocyte-macrophage colony-stimulating factor (GM-CSF) elevated in temporal artery biopsies (TABs) of patients with GCA
- p16- and p21-expressing cells mainly near the internal lamina elastica, especially among giant cells and macrophages; found in all 3 vessel layers
- p16 and p21 expression occasionally in T cells but not B cells
- p16+ and p21+ cells expressing GM-CSF/IL-6 detected throughout the TABs
Original publication
Indication of Activated Senescence Pathways in the Temporal Arteries of Patients With Giant Cell Arteritis. Arthritis Rheumatol. Published 28 June 2023. doi:10.
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