Vasculitis & polymyalgia rheumatica
Transorbital ultrasound in the diagnosis of giant cell arteritis
Authors' conclusion
Our findings suggest reduced central retinal artery flow and increased optic nerve diameter as potential biomarkers for serious ocular involvement in GCA.
Study context
- Population
- Patients with newly diagnosed, untreated giant cell arteritis (GCA), with and without visual symptoms, and healthy controls54 GCA patients and 27 controls
- Participants
- 27 vs 27
- Comparison
- GCA patients with visual symptoms vs healthy controls
- GCA with visual symptomsn = 27
- Healthy controlsn = 27reference
- Outcome
- Diagnostic efficacy of TOS: central retinal artery PSV, EDV, RI and optic nerve diameter (OND)
Methodological detailscase-control
- Case-control
Performance
As reported in the abstract
Β (peak systolic velocity (PSV))
−1.91
P = 0.029
significantly lower PSV
Β (end-diastolic velocity (EDV))
−0.57
P = 0.032
significantly lower EDV
Β (optic nerve diameter (OND))
0.79
P = 0.003
significantly elevated OND
- Resistance index (RI) did not significantly differ from controls (β = −0.06)
- P = 0.129
Further findings
| Outcome | Values |
|---|---|
| Pathological vessels per GCA patient on vascular US | GCA average 8.7 (SD ± 2.8) vessels |
Association of number of affected vessels with TOS measures
- Significant negative association with PSV
- P = 0.048
- Significant negative association with EDV
- P = 0.040
- No association with RI
- P = 0.249
- Positive significant association with OND
- P < 0.001
Original publication
Transorbital ultrasound in the diagnosis of giant cell arteritis. Rheumatology (Oxford). Published 17 May 2024. doi:10.
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