Vasculitis & polymyalgia rheumatica
Serum citrullinated histone H3 as a biomarker of disease activity and renal outcome in microscopic polyangiitis and granulomatosis with polyangiitis
Authors' conclusion
Serum CitH3 correlated with disease activity, demonstrated strong discriminatory performance for severe disease and acceptable discriminatory performance for low disease activity states, and was associated with an increased risk of ESKD.
Study context
- Population
- Patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA); serum CitH3 measured and Birmingham Vasculitis Activity Score (BVAS) assessed at diagnosis
- Participants
- 65 patients
- Outcome
- Utility of serum CitH3 as a biomarker for disease activity (BVAS) and risk of ESKD
- Follow-up
- At diagnosis
Methodological detailsmultivariable Cox regression, ROC curve analysis
- Multivariable Cox regression
- ROC curve analysis
Main finding
As reported in the abstract
- Correlation of serum CitH3 with BVAS (Pearson r)
- r = 0.393, p = 0.001
- AUC of serum CitH3 for severe disease (BVAS ≥ 20)
- 0.905, 95% CI 0.825-0.984, p < 0.001
- AUC of serum CitH3 for low disease activity states (BVAS ≤ 3)
- 0.703, 95% CI 0.558-0.848, p = 0.013
- Patients developing end-stage kidney disease (ESKD) (mean follow-up 38.3 ± 32.8 months)
- 8 (12.3%)
- Higher serum CitH3 and ESKD risk, aHR (adjusted for age and serum creatinine)
- 1.181, 95% CI 1.033-1.352, p = 0.015
Observational data: associations, not effects.
Original publication
Serum citrullinated histone H3 as a biomarker of disease activity and renal outcome in microscopic polyangiitis and granulomatosis with polyangiitis. Arthritis Res Ther. Published 18 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →