Vasculitis & polymyalgia rheumatica
The clinical potential of serum autotaxin levels at diagnosis as a biomarker for current activity and subsequent complications in patients with microscopic polyangiitis and granulomatosis with polyangiitis
Authors' conclusion
In the present study, we demonstrated the clinical potential of serum ATX levels at diagnosis as a useful indicator for assessing current activity and as a predictor of subsequent ACM in patients with MPA or GPA.
Study context
- Population
- Patients with microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA), serum autotaxin (ATX) measured in samples collected and stored at diagnosispatients with MPA or GPA
- Participants
- 72 patients
- Exposure
- Serum ATX ≥713.9 ng/mL vs serum ATX <713.9 ng/mL
- Outcome
- Correlation of serum ATX levels with BVAS, C-reactive protein and serum albumin levels
- Follow-up
- At diagnosis
Methodological detailsmultivariable Cox proportional hazards analysis
- Multivariable Cox proportional hazards analysis
Main finding
As reported in the abstract
- Serum ATX levels significantly correlated with Birmingham Vasculitis Activity Score (BVAS), C-reactive protein, and serum albumin levels
Observational data: associations, not effects.
Further findings
Serum ATX levels at diagnosis in deceased vs surviving patients
- Significantly higher in deceased patients than in surviving patients
Cumulative patients' survival rate
- Significantly lower with serum ATX ≥713.9 ng/mL than with serum ATX <713.9 ng/mL
- Cut-off value of ≥713.9 ng/mL for serum ATX to predict subsequent all-cause mortality (ACM)
Subsequent all-cause mortality (ACM)
- Serum ATX ≥713.9 ng/mL significantly and independently associated with subsequent ACM
- Multivariable Cox proportional hazards analysis
Original publication
The clinical potential of serum autotaxin levels at diagnosis as a biomarker for current activity and subsequent complications in patients with microscopic polyangiitis and granulomatosis with polyangiitis. Clin Exp Rheumatol. Published 6 January 2026. doi:10.
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