Vasculitis & polymyalgia rheumatica
Distinct molecular signature in relapsed patients with ANCA-associated vasculitis
Authors' conclusion
In this well-defined MPA/GPA cohort, we report for the first time a distinct relapse-associated transcriptional signature consistent with enhanced neutrophil activity.
Study context
- Population
- Patients with microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA)21 patients · 12 controls
- Participants
- 6 / 5 / 4 / 6 / 12
- Comparison
- Relapsed vs newly diagnosed, remission and healthy controls
- Newly diagnosedn = 6
- Relapsedn = 5
- Remission on maintenance therapyn = 4
- Remission off maintenance therapyn = 6
- Healthy controlsn = 12reference
- Outcome
- Whole blood transcriptional profile
Methodological detailswhole blood RNA sequencing, differential gene expression and functional enrichment analysis, age-matched/sex-matched healthy controls
- Whole blood RNA sequencing
- Differential gene expression and functional enrichment analysis
- Age-matched/sex-matched healthy controls
Main finding
As reported in the abstract
- Major relapse: unique pattern of neutrophil degranulation-associated genes (granular proteins, adhesion and chemotaxis, myelopoiesis)
- 41
Original publication
Distinct molecular signature in relapsed patients with ANCA-associated vasculitis. RMD Open. Published 23 September 2026. doi:10.
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