Vasculitis & polymyalgia rheumatica
Comparative analysis of arterial involvement in predominant cranial and isolated extracranial phenotypes of giant cell arteritis using 18F-FDG PET-CT
Authors' conclusion
Significant differences in arterial involvement patterns on 18F-FDG PET-CT were observed between phenotypes.
Study context
- Population
- Patients with confirmed giant cell arteritis (GCA) who underwent 18F-FDG PET-CT90 women
- Participants
- 140 patients
- Exposure
- Predominant cranial vs isolated extracranial GCA phenotype
- Cranialn = 99reference
- Isolated extracranialn = 41
- Outcome
- Arterial involvement patterns on 18F-FDG PET-CT
Methodological detailsretrospective review of 18F-FDG PET-CT findings
- Retrospective review of 18F-FDG PET-CT findings
Main finding
As reported in the abstract
Arterial involvement on 18F-FDG PET-CT
- Greater involvement across all segments of the thoracic aorta in extracranial phenotype
- p = 0.001
- Greater abdominal aorta involvement in extracranial phenotype
- p = 0.005
- Greater subclavian artery involvement in extracranial phenotype
- p = 0.021
- Greater iliac artery involvement in extracranial phenotype
- p = 0.004
- Greater femoral artery involvement in extracranial phenotype
- p = 0.025
- Higher frequency of vertebral artery involvement in cranial phenotype
- p < 0.001
Observational data: associations, not effects.
Further findings
Temporal artery biopsy (TAB) positivity, extracranial phenotype
- Lower TAB positivity in extracranial phenotype
- 25%
Age
- Extracranial phenotype younger
- P = 0.001
Diagnostic delay
- Longer diagnostic delays in extracranial phenotype
- P = 0.004
PMR
- PMR more common in extracranial group
- P = 0.029
Constitutional symptoms, acute phase reactants, limb claudication, aortic complications
- Extracranial group: fewer constitutional symptoms, milder increases in acute phase reactants, more frequent limb claudication and aortic complications; differences not statistically significant
Original publication
Comparative analysis of arterial involvement in predominant cranial and isolated extracranial phenotypes of giant cell arteritis using 18F-FDG PET-CT. Arthritis Res Ther. Published 28 December 2024. doi:10.
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