Vasculitis & polymyalgia rheumatica
Clinical phenotype and complications of large vessel giant cell arteritis: A systematic review and meta-analysis
Authors' conclusion
Patients with LV-GCA have distinct disease features when compared to C-GCA
Study context
- Population
- Cohort or cross-sectional studies of ≥25 patients with large-vessel GCA (LV-GCA) (MEDLINE and EMBASE to 7 May 2021)46 studies
- Comparison
- Large-vessel Giant Cell Arteritis (GCA) vs limited cranial GCA
- Outcome
- LV-GCA vs C-GCA clinical features
Methodological detailsrandom effects meta-regression
- Random effects meta-regression
Pooled result
As reported in the abstract
LV-GCA vs C-GCAOdds ratio (95% CI)
Positive temporal artery biopsy
0.52(0.3–0.91)
- Age at diagnosis
- mean age difference −4.53 years
- Delay to diagnosis
- mean difference 3.03 months
- LV-GCA meeting 1990 ACR Classification Criteria for GCA
- 53%
Further pooled results
- Cumulative prednisolone dose, LV-GCA · 12 months
- 6056.5 · mean · mg
- Deaths in LV-GCA directly attributable to an large vessel (LV) complication
- 12%
Relapse
- Relapse rates similar between LV- and cranial GCA (C-GCA)
Vasculitis site
- Most common in thoracic aorta, then subclavian, brachiocephalic trunk and axillary arteries
Original publication
Clinical phenotype and complications of large vessel giant cell arteritis: A systematic review and meta-analysis. Joint Bone Spine. Published 28 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →