Vasculitis & polymyalgia rheumatica
Intracranial GCA: a comprehensive systematic review
Authors' conclusion
Our findings suggest that ICGCA is not a rare entity and may represent a more severe manifestation of GCA.
Study context
- Population
- Reported cases of intracranial GCA (ICGCA; any vessel cranial to the dura mater, confirmed by histopathology or imaging) in MEDLINE, Embase and PubMed
- Participants
- 340 cases102 studies
- Outcome
- Presentations, vessels involved, treatment and outcomes of ICGCA
Methodological detailsdescriptive statistics
- Descriptive statistics
Pooled result
As reported in the abstract
- Median age, years (IQR 71.9-77.3)
- 73.7
- Female
- 46.9%
- Presentation: stroke
- 240 (70.6%)
- Presentation: isolated intracranial imaging or histologic changes
- 67 (19.7%)
- Vertebrobasilar involvement
- 180 (52.9%)
- Internal carotid involvement
- 166 (48.8%)
- Ophthalmic artery involvement
- 49 (14.4%)
- GC administered (of 214 with reported treatment)
- 210 (98.1%)
- Relapse (of 181 with reported follow-up)
- 40 (22.1%)
- Died (of 181 with reported follow-up)
- 59 (32.6%)
Original publication
Intracranial GCA: a comprehensive systematic review. Rheumatology (Oxford). Published 25 March 2025. doi:10.
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