Vasculitis & polymyalgia rheumatica
An update on stroke and transient ischemic attack in Takayasu arteritis: A systematic review and meta-analysis
Authors' conclusion
TA patients face a high burden of stroke/TIA, with marked heterogeneity driven by population and methodological differences. Males and Europeans have higher prevalence of stroke/TIA. Smoking is the only modifiable risk factor in TA patients with stroke/TIA.
Study context
- Population
- TAK patients; 8 databases (PubMed, EMBASE, Web of Science, Medline, four Chinese databases) searched up to January 2025
- Participants
- 5,112 patients34 cohort studies
- Outcome
- Pooled prevalence of stroke/TIA in TAK
Methodological detailsrandom-effects model, PRISMA and MOOSE guidelines, subgroup analyses
- Random-effects model
- PRISMA and MOOSE guidelines
- Subgroup analyses
Pooled result
As reported in the abstract
Pooled prevalence of stroke/transient ischemic attack (TIA)
10.7%
95% CI 8.4%–13.6%
Heterogeneity I2
90.4%
Further pooled results
Stroke/TIA prevalence by sex (subgroup)
Smoking as risk factor for stroke/TIA (sole significant modifiable risk factor)
| RR (95% CI) | ||
|---|---|---|
| Smoking | 1.64 (1.13–2.38) | |
| 0.512Relative risk (log scale) |
Stroke/TIA prevalence in European populations (subgroup)
- Prevalence in European populations (higher)
- 13%
Stroke type
- Ischemic stroke prevalence (predominated; I2=80.7%)
- 7%
- Hemorrhagic stroke prevalence (rare; I2=0%)
- 2%
Stroke as share of all TAK-related deaths
- Proportion of TAK-related deaths due to stroke
- 21.2%
Original publication
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