Vasculitis & polymyalgia rheumatica
Association between cardiovascular risk factors and the occurrence of giant cell arteritis: a systematic review and meta-analysis
Authors' conclusion
Our study showed an inverse association between type 2 diabetes and risk of GCA, and a positive association between a history of cardiovascular disease and risk of GCA. It also identified a trend towards an inverse association between overweight and risk of GCA.
Study context
- Population
- Epidemiological studies on CV risk factors and risk of GCA (Medline, Embase, Web of Science)17 studies in meta-analysis
- Comparison
- Six CV risk factors vs their absence
- Outcome
- Onset of GCA
Methodological detailsROBINS-E risk of bias assessment, pooled odds ratios (ORs)
- ROBINS-E risk of bias assessment
- Pooled ORs
Pooled result
As reported in the abstract
Risk of GCA by CV risk factor
Type 2 diabetes, OR
0.75 (0.61-0.93) (95% CI)
History of CVD, OR
1.28 (1.18-1.38) (95% CI)
Overweight, OR (95% CI) (trend towards decreased risk)
0.64
0.41–1.00
Original publication
Association between cardiovascular risk factors and the occurrence of giant cell arteritis: a systematic review and meta-analysis. Rheumatology (Oxford). Published 24 March 2025. doi:10.
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