Vasculitis & polymyalgia rheumatica
Incidence of aortic aneurysm, dissection, or rupture among patients with polymyalgia rheumatica and giant cell arteritis
Authors' conclusion
Patients with PMR had a similar risk of large vessel complications compared to the general population and a lower risk compared to those with GCA.
Study context
- Population
- Patients with PMR and giant cell arteritis (GCA) and matched general population controls, US-based TriNetX database (2000–2024)median follow-up 3.74 years
- Participants
- 57,336 patients
- Exposure
- GCA and matched general population vs PMR
- PMRn = 17,327reference
- GCAn = 4,734
- General populationn = 35,275
- Outcome
- Aortic complications: composite of aortic aneurysm and dissection/rupture
Methodological detailsmatched general population controls (1:3 ratio), Cox proportional cause-specific hazard models
- Matched general population controls (1:3 ratio)
- Cox proportional cause-specific hazard models
Main finding
As reported in the abstract
Any aortic complication
Each group vs PMRAdjusted hazard ratio (95 % CI)
GCA
1.87(1.58–2.21)
General population
0.95(0.84–1.06)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95 % CI) | |
|---|---|---|
| Any aortic complication, PMR who later developed GCAvs initially diagnosed GCA (sensitivity analysis)Sensitivity analysis | 0.85 (0.60–1.19) | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
Incidence of aortic aneurysm, dissection, or rupture among patients with polymyalgia rheumatica and giant cell arteritis. Semin Arthritis Rheum. Published 15 March 2025. doi:10.
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