Vasculitis & polymyalgia rheumatica
Subclinical aortic inflammation in patients with polymyalgia rheumatica
Authors' conclusion
Some patients with PMR have subclinical aortic inflammation that is detectable many years after initial diagnosis and may contribute to the development of aortic aneurysm.
Study context
- Population
- Patients with Current Procedural Terminology (CPT) codes for thoracic aorta repair surgery at Mayo Clinic, Rochester, MN, 2000–2021screened
- Participants
- 4,621 patients
- Exposure
- Clinically isolated PMR vs giant cell arteritis (GCA), both with thoracic aorta repair surgery
- PMRn = 43
- Outcome
- Active inflammation on histopathological examination of aortic tissue
Methodological detailssingle-centre, histopathological re-examination of aortic tissue
- Single-centre
- Histopathological re-examination of aortic tissue
Main finding
As reported in the abstract
Active aortic inflammation in PMR · median (IQR) 10.0 (4.7-13.3) years from PMR diagnosis
PMR
70%
30 of 43
Observational data: associations, not effects.
Further findings
Severe (Grade 3) aortic inflammation
P = 0.002
| Outcome | Standardized mortality ratio (95% CI) |
|---|---|
| Mortality in PMR vs general populationDid not reach statistical significance | 1.40 (0.91–2.07) |
- Severe (Grade 3) aortic inflammation: PMR denominator 30 (with active inflammation); GCA denominator 34
Original publication
Subclinical aortic inflammation in patients with polymyalgia rheumatica. Rheumatology (Oxford). Published 18 July 2024. doi:10.
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