Vasculitis & polymyalgia rheumatica
Gastrointestinal lesions of eosinophilic granulomatosis with polyangiitis: a prediction model and clinical patterns
Authors' conclusion
Severe gastrointestinal lesions are common in EGPA and early detection is critical. Eosinophils are an important factor associated with gastrointestinal involvement of EGPA. We developed a model to predict the risk of gastrointestinal lesions.
Study context
- Population
- Patients with eosinophilic granulomatosis with polyangiitis (EGPA)
- Participants
- 165 patients
- Exposure
- EGPA with vs without gastrointestinal lesions
- Gastrointestinal lesionsn = 52
- Severe gastrointestinal lesionsn = 22
- Outcome
- Predictive model for gastrointestinal lesions in EGPA
Methodological detailsmultivariate logistic regression, nomogram
- Multivariate logistic regression
- Nomogram
Main finding
As reported in the abstract
Gastrointestinal lesions
Patients with gastrointestinal lesions
52
Developed severe disorders
22
Eosinophil ratio identifying GI lesions
over 19.2%
Observational data: associations, not effects.
Further findings
Common GI manifestations
- Abdominal pain
- 78%
- Diarrhea
- 40.4%
- Nausea and/or vomiting
- 32.7%
Severe GI lesions
- Hemorrhage
- 26.9%
- Ulcers
- 17.3%
- Obstruction
- 9.6%
- Pancreatitis
- 5.8%
Features of severe GI lesions
- Shorter duration from initial symptoms to EGPA diagnosis, less frequent asthma and ear-nose-throat involvement, more likely to receive methylprednisolone pulse
Five Factor Score ≥ 2
- Significantly more patients with GI involvement had a Five Factor Score ≥ 2
Clinical patterns
- Five well-defined clinical models identified, including the brain-gut pattern
Original publication
Gastrointestinal lesions of eosinophilic granulomatosis with polyangiitis: a prediction model and clinical patterns. Arthritis Res Ther. Published 4 January 2025. doi:10.
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