Vasculitis & polymyalgia rheumatica
Prediction of Relapse and Glucocorticoid Dependence in Eosinophilic Granulomatosis With Polyangiitis: Findings From a Large European Cohort
Authors' conclusion
Using a large cohort with EGPA, we developed predictive models for vasculitis relapse and GC-dependent asthma and/or ENT symptoms.
Study context
- Population
- Patients with eosinophilic granulomatosis with polyangiitis (EGPA) fulfilling the 2022 ACR/EULAR criteria, multicentre European cohortmedian follow-up 72 months
- Participants
- 809 patients
- Outcome
- Vasculitis relapse and GC-dependent asthma and/or ENT symptoms (prediction models)
Methodological detailsmulticentre, prediction model development, Fine-Gray and logistic regression, internal validation by bootstrapping
- Multicentre
- Prediction model development
- Fine-Gray and logistic regression
- Internal validation by bootstrapping
Main finding
As reported in the abstract
Vasculitis relapse · 12 years
- Patients with vasculitis relapse
- 228
- 12-year cumulative incidence of vasculitis relapse
- 41.2% (95% CI 36.3-46.8)
- Predictor: GC-dependent asthma before EGPA diagnosis, HR
- 1.57
- Predictor: arthralgia, HR
- 1.27
- Predictor: myocarditis, HR
- 1.74
- Predictor: peripheral neuropathy, HR
- 1.39
- Predictor: MPO-ANCA, HR
- 1.56
Observational data: associations, not effects.
Further findings
- Proportion with GC-dependent asthma and/or ear, nose, and throat (ENT) symptoms at two years
- 66.4%
- Predictor: older age, OR per year
- 0.98
- Predictor: GC-dependent asthma at diagnosis, OR
- 1.50
- Predictor: chronic sinusitis, OR
- 1.78
- Predictor: baseline eosinophil count, OR per 109/L
- 0.70
Original publication
Prediction of Relapse and Glucocorticoid Dependence in Eosinophilic Granulomatosis With Polyangiitis: Findings From a Large European Cohort. Arthritis Rheumatol. Published 16 March 2026. doi:10.
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