Vasculitis & polymyalgia rheumatica
Cluster Analysis to Explore Clinical Subphenotypes of Eosinophilic Granulomatosis With Polyangiitis
Authors' conclusion
Although reinforcing the known association of ANCA status with clinical manifestations, cluster analysis does not support a complete separation of EGPA in ANCA-positive and -negative subsets.
Study context
- Population
- Patients with eosinophilic granulomatosis with polyangiitis (EGPA) fulfilling widely accepted classification criteria, 15 European centres, diagnosed 1984–2015
- Participants
- 489 patients
- Exposure
- ANCA-positive vs ANCA-negative EGPA; clinical clusters with and without ANCA
- Outcome
- Clinical clusters
Methodological detailsmulticentre (15 European centres), multiple correspondence analysis, hierarchical cluster analysis, decision tree model
- Multicentre (15 European centres)
- Multiple correspondence analysis
- Hierarchical cluster analysis
- Decision tree model
Main finding
As reported in the abstract
Clusters generated, model without ANCA
4
Clusters generated, model with ANCA
5
Both models identified 3 identical clusters (by presence or absence of ENT, CNS and ophthalmological involvement); patients per cluster
34, 39, and 40
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Clinical features, ANCA-positive vs ANCA-negativeANCA-positive vs ANCA-negative · more renal involvement | P < 0.001 |
| Clinical features, ANCA-positive vs ANCA-negativeANCA-positive vs ANCA-negative · more peripheral neurological involvement | P = 0.04 |
| Clinical features, ANCA-positive vs ANCA-negativeANCA-positive vs ANCA-negative · fewer cardiovascular signs | P < 0.001 |
| Clinical features, ANCA-positive vs ANCA-negativeANCA-positive vs ANCA-negative · fewer biopsies with eosinophilic tissue infiltrates | P = 0.001 |
ANCA detected
- ANCA-positive patients
- 37.2%
- Perinuclear ANCA among ANCA-positive
- 85.4%
- Antimyeloperoxidase among ANCA-positive
- 87%
Original publication
Cluster Analysis to Explore Clinical Subphenotypes of Eosinophilic Granulomatosis With Polyangiitis. J Rheumatol. Published 22 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →