Vasculitis & polymyalgia rheumatica
Evaluation of therapeutic plasma exchange in anti-neutrophil cytoplasmic antibody-associated vasculitis in real-life settings: long-term results of propensity score matching analysis in high-risk patients
Authors' conclusion
We did not demonstrate a positive effect of TPE on remission, ESRD, and mortality in AAV in this study.
Study context
- Population
- Patients diagnosed with antibody-associated vasculitis (AAV) 2011–2021 with baseline estimated glomerular filtration rate (eGFR) ≤ 50 mL/min/1.73m2 or diffuse alveolar haemorrhageinitial propensity score matching (PSM) cohort n = 48
- Participants
- 71 patients
- Exposure
- Therapeutic plasma exchange (TPE) vs no TPE in high-risk AAV
- Outcome
- Remission rate (initial PSM cohort)
- Follow-up
- 6 months
Methodological detailspropensity-score matched, two PSM models (initial and data-driven)
- Propensity-score matched
- Two PSM models (initial and data-driven)
Main finding
As reported in the abstract
- Remission rate at 6 months lower in the TPE group
- TPE vs No TPE: P = 0.04
- Initial PSM cohort (n = 48)
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| ESRD (initial PSM cohort) · 12 monthsTPE vs No TPE · higher in the TPE group | P = 0.02 |
Mortality and eGFR improvement (initial PSM cohort) · 6 and 12 months
- No significant differences
All outcomes (data-driven PSM, n = 44)
- No significant differences between groups
Safety
| Outcome | P value |
|---|---|
| Serious infections (initial PSM cohort) · 12 monthsTPE vs No TPE · higher in the TPE group | P = 0.016 |
Severe complications due to TPE
- None observed
- 0
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Evaluation of therapeutic plasma exchange in anti-neutrophil cytoplasmic antibody-associated vasculitis in real-life settings: long-term results of propensity score matching analysis in high-risk patients. Scand J Rheumatol. Published 24 March 2025. doi:10.
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