Vasculitis & polymyalgia rheumatica
Longitudinal Patterns of Renal Function in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis
Authors' conclusion
We identified 4 longitudinal patterns of renal function after AAV diagnosis.
Study context
- Population
- Antibody-associated vasculitis (AAV) patients with ≥2 creatinine measurements, including at baseline (±30 days of treatment initiation), Mass General Brigham AAV Cohort
- Participants
- 255 patients
- Exposure
- Renal trajectory groups identified by longitudinal estimated glomerular filtration rate (eGFR) change
- Rapid declinen = 20
- Impairedn = 82
- Preservedn = 129
- Recoveryn = 24
- Outcome
- Longitudinal trajectory of renal function (eGFR)
Methodological detailsgroup-based trajectory model
- Group-based trajectory model
Main finding
As reported in the abstract
Renal trajectory groups identified
- 4 renal trajectory groups identified: rapid decline, impaired, preserved, recovery
Observational data: associations, not effects.
Further findings
| Outcome | Rapid decline | Impaired | Preserved | P value |
|---|---|---|---|---|
| Clinically significant CKD (eGFR <60 ml/minute/1.73 m²) persisting · over 5 yearsImpaired vs Preserved | — not stated in the abstract | >75% | <40% | P < 0.001 |
| ESRD | 100% | 7% | 7% |
— not stated in the abstract
Baseline comorbidity
- Greater baseline comorbidity in the rapid decline and impaired groups
- P = 0.01
Prevasculitis eGFR
- Lower prevasculitis eGFR in the rapid decline and impaired groups
- P = 0.02
End-stage renal disease (ESRD) etiology attributed to vasculitis
- Rapid-onset ESRD attributed to vasculitis
- 90%
- ESRD attributed to vasculitis in impaired or preserved groups
- 17-44%
- Difference in ESRD etiology
- P = 0.001
- Baseline AAV renal involvement present prior to ESRD
- 95%
Original publication
Longitudinal Patterns of Renal Function in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis. Arthritis Care Res (Hoboken). Published 9 March 2023. doi:10.
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