Vasculitis & polymyalgia rheumatica
Paediatric-onset Takayasu's arteritis associates with worse survival than adult-onset Takayasu's arteritis. A matched retrospective cohort study
Study context
- Population
- Retrospective cohort of patients with TAK
- Participants
- 56 vs 135
- Exposure
- Paediatric-onset vs adult-onset TAK
- Paediatric-onset TAKn = 56
- Adult-onset TAKn = 135reference
- Outcome
- Mortality (survival)
Methodological detailspropensity-score matched, multivariable-adjusted logistic regression
- Propensity-score matched
- Multivariable-adjusted logistic regression
Main finding
As reported in the abstract
Mortality
Paediatric-onset TAK vs Adult-onset TAKHazard ratio (95% CI)
Unadjusted
6.13(1.51–24.91)
Adjusted for prognostic covariates (gender, diagnostic delay, baseline disease activity, number of csDMARDs and b/tsDMARDs used)
4.97(1.20–20.58)
Adjusted for differences between groups
5.54(1.22–25.09)
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | |
|---|---|---|
| Presentation and angiographic features more frequent in paediatric-onset TAKPaediatric-onset TAKvs Adult-onset TAKChest pain | 3.21 (1.06–9.74) | |
| Presentation and angiographic features more frequent in paediatric-onset TAKPaediatric-onset TAKvs Adult-onset TAKHF | 3.16 (1.05–9.53) | |
| Presentation and angiographic features more frequent in paediatric-onset TAKPaediatric-onset TAKvs Adult-onset TAKHeadache | 2.60 (1.01–6.74) | |
| Presentation and angiographic features more frequent in paediatric-onset TAKPaediatric-onset TAKvs Adult-onset TAKAscending aorta involvement | 3.02 (1.04–8.80) | |
| Presentation and angiographic features more frequent in paediatric-onset TAKPaediatric-onset TAKvs Adult-onset TAKLeft renal artery involvement | 2.45 (1.04–5.80) | |
| 0.10.31310Adjusted odds ratio (log scale) |
Original publication
Paediatric-onset Takayasu's arteritis associates with worse survival than adult-onset Takayasu's arteritis. A matched retrospective cohort study. Clin Exp Rheumatol. Published 7 March 2023. doi:10.
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