Vasculitis & polymyalgia rheumatica
Elevated serum immunoglobulin level predicts high risk of 1-year recurrence in patients with Takayasu arteritis
Authors' conclusion
Immunoglobulins is of clinical value in evaluating disease activity in TAK patients. Moreover, the dynamic changes of IgG were correlated with the changes in inflammatory indicators in TAK patients.
Study context
- Population
- Patients with TAK; 120 in remission within 3 months after discharge followed up for 1 year120 followed up 1 year
- Participants
- 190 patients
- Exposure
- Elevated vs normal immunoglobulins
- Outcome
- Disease activity
Methodological detailslogistic regression, immunohistochemical comparison with atherosclerotic patients
- Logistic regression
- Immunohistochemical comparison with atherosclerotic patients
Main finding
As reported in the abstract
| Group | Value | ITAS-A |
|---|---|---|
| Elevated immunoglobulins | 3.0 | 9.0 |
| Normal | 2.0 | 7.0 |
Value
Elevated immunoglobulins3.0
Normal2.0
ITAS-A
Elevated immunoglobulins9.0
Normal7.0
- Elevated immunoglobulins vs Normal: P = 0.001
- Elevated immunoglobulins vs Normal: P = 0.006
Observational data: associations, not effects.
Further findings
| Outcome | OR for 1-year recurrence (95% CI) | P value | |
|---|---|---|---|
| 1-year recurrence in TAK patients in remission within 3 months after discharge (n=120), elevatedvs normal immunoglobulinsLogistic regression | 2.37 (1.03–5.47) | P = 0.042 | |
| 0.20.5125OR for 1-year recurrence (log scale) |
| Outcome | P value |
|---|---|
| CD138+ plasma cells in the aortic wall (immunohistochemistry), TAK vs atherosclerotic patientsSignificantly increased in TAK | P = 0.021 |
Correlation of changes in IgG with CRP and ESR
- IgG change vs CRP, Pearson r (P = 0.027)
- 0.40
- IgG change vs ESR, Pearson r (P < 0.001)
- 0.64
Original publication
Elevated serum immunoglobulin level predicts high risk of 1-year recurrence in patients with Takayasu arteritis. Arthritis Res Ther. Published 7 March 2023. doi:10.
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