Vasculitis & polymyalgia rheumatica
Elevated serum uric acid is a predictor of pulmonary artery involvement and subsequent prognosis in patients with Takayasu's arteritis
Main finding · Incidence of PAI, serum UA level ≥284.5 umol/L (multivariate logistic regression)Result — go to the resultOdds ratio 2.108 95% CI 1.063–4.180Authors' conclusion
Elevation of serum UA level was associated with an increasing risk of PAI and PAI-related adverse event in patients with TAK
Study context
- Population
- Patients with TAK144 followed up
- Participants
- 166 patients
- Exposure
- Serum uric acid (UA) level ≥284.5 umol/L vs lower (PAI incidence); serum UA level ≥328.1 umol/L vs <328.1 umol/L (PAI-related prognosis)
- PAIn = 76
- Without PAIn = 90reference
- Outcome
- Predictive value of UA in prognosis of PAI in TAK
Methodological detailsmultivariate logistic regression, Kaplan-Meier survival analysis, multivariate Cox proportional hazard regression
- Multivariate logistic regression
- Kaplan-Meier survival analysis
- Multivariate Cox proportional hazard regression
Main finding
As reported in the abstract
Incidence of PAI, serum UA level ≥284.5 umol/L (multivariate logistic regression)
Odds ratio
2.108
95% CI 1.063–4.180
P = 0.033
UA ≥284.5 umol/L
OR 2.108 (95% CI 1.063–4.180); P = 0.033
Observational data: associations, not effects.
Further findings
PAI-related adverse events, serum UA level ≥328.1 umol/L
| HR (95% CI) | P value | ||
|---|---|---|---|
| UA ≥328.1 umol/L | 2.595 (1.198–5.622) | P = 0.016 | |
| 0.20.5125Hazard ratio (log scale) |
| Outcome | P value |
|---|---|
| PAI-related adverse events, serum UA level ≥328.1 umol/LUA ≥328.1 umol/L vs UA <328.1 umol/L · significantly higher cumulative incidence | P = 0.008 |
- PAI-related adverse events, serum UA level ≥328.1 umol/L: multivariate Cox regression; PAI-related prognostic risk factor
Original publication
Elevated serum uric acid is a predictor of pulmonary artery involvement and subsequent prognosis in patients with Takayasu's arteritis. Clin Exp Rheumatol. Published 3 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →